ANCHR regulates TRAIL-mediated apoptosis with implications for liver injury

Abstract

Apoptotic cell death is essential for maintaining liver homeostasis, and its dysregulation contributes to liver diseases, which can lead to fibrosis and end-stage liver failure. Tumour Necrosis Factor-Related Apoptosis-Inducing Ligand (TRAIL) signalling is a key regulator of hepatobiliary apoptosis, yet the mechanisms that govern TRAIL sensitivity remain poorly defined. Here, we identify the Abscission/NoCut Checkpoint Regulator (ANCHR) and its interacting E3 ubiquitin ligase Mind Bomb 2 (MIB2) as novel modulators of death receptor-mediated apoptosis, with a particular emphasis on TRAIL signalling. Specifically, we show that ANCHR protects cancer cells from TRAIL-induced apoptosis by limitin..